I would do the Clans as Bioforms with the bioform advantages being, instead of any Attribute bonuses, the Clan Disciplines. You get the normal 3-4 points to distribute into them.
And naturally with each Bioform/Clan comes a weakness.
Brujah: Frenzy checks are always HARD.
Toreador: Has to make a Wisdom check to not become enthralled when witnessing a thing of beauty, whether art or a natural wonder or something else. GM decides whether to check as EAS, NORMAL or HARD depending on the stimuly.
Ventrue: Must choose a specific feeding preference, must check for Frenzy if accidentally feeds on the wrong Blood.
Malkavian: Must choose a derangement for the character to suffer from, this may cause checks or otherwise compromise the character. GM must agree to your infliction and will occasionally describe things to your character that may or may not be caused by your ailment.
Tremere: Will be fully Bloodbound through only two drinks and has to check any Dominate resists from higher ranking manners at HARD.
Nosferatu: You are one ugly m* f*. Test HARD for any positive social interactions if appearance can be an issue, test EASY for most intimidating actions.
Gangrel: Gain animalistic features from Frenzying. The features will vanish in a session or two but after a particularly brutal or long Frenzy they may gain a permanent feature, generally if humanity/road loss is involved.
Tzimisce: You must sleep in atleast two handfuls of your native soil. If this condition is not met everything is HARD untill you get to sleep on proper soil.
Lasombra: You cast no reflection and appear in no photographs, in fact the only way to see yourself is through paintings which can be really inconvenient if you need to check your hair, or if you have Blood on you face Etc. This may also have profound psychological effects in the long term where you start to forget what you look like and thus erodes your self image. Some are may become downright obsessive about their appearance always having servants around telling them how they look Etc.
Children of Set: Take double damage from sunlight and particularly bright lights may cause things to become HARD for you.
Assamites: Warriors are addicted to Vitae and must test HARD to stop feeding on a Cainite they have tasted the Blood of. ( If playing during the Tremere Curse Warriors take damage from drinking Vitae and cannot commit Diablerie as a result, to lower their generation they must bring a large quantity of Vitae back to Alamut for the Sorcerer cast to use in a ritual )
Sorcerers: Their Auras are bright and always show Magic use in them, reading their aura is EASY.
Viziers: All Viziers are Obsessive-Compulsive towards their current intellectual focus whatever that may be.
Giovanni: Unlike other Cainites their Kiss is not a blissful affair but excruciating one. Their Kiss causes double the damage similar bloodloss would cause. Also their victims may be paralyzed by their pain but silent they are not.
Ravnos: The Beast of the Ravnos are no monsters filled with blind rage but cunning daemons luring them from their Paths. Beast of the Ravnos has a favourite Vice that they try to goad the Cainite to fullfill, if presented with the chosen Vice the Cainite must test Wisdom at a difficulty determined by how enticing the opportunity to indulge in the Vice is.
Baali: Members of the First Tribe take double damage from True Faith based attacks and must always test for Faith induced Rötchreck at HARD.
This is just how I would go about doing this if I wanted to change systems.