As an example: For a Dungeon Crawl, Maybe every time the Timer hits, roll the Blue one. Every time someone searches successfully, Roll the Yellow one.
BLUE Dungeon Peril Die
Fist(2): First—Single Goblin Scout; Second on—Scavenged Corpses of Unlucky Adventurers
Sword(1): First—d4 1H Ambushing Rogues; Second: Corroder Beast; Third on—2 Heart Goblin Pack
Eye(1): First—Collapsing Wall Save or D8 damage; Second: Sounds of distant battle…zaps!..screams!; Third on: Odd Tracks (Duergar leading to a previously unknown alternate exit…into the Undermountain)
Shield(1): Each Time: Target +1 due to an Environmental Effect (smoke, fumes, magical darkness)
Block Tentacle(1): First—Eye Beast (withdraws after 2 Hearts damage); Second on—Eye Beast returns to finish job, with help!
YELLOW Successful Search Die
Fist(2): Surface—D3 Supplies or 2d10 Coin/Valuables; Lower Level—Gem or Jewelry d8 x d10 coins in value.
Crit Fist(1): Surface—Shabby Loot; Lower Level—Ancient Loot
Tentacle(1): Surface—Cursed Loot; Lower Level—Epic Loot
Blank(1): Surface—Written Material/Map ; Lower Level—The Big Bad’s Kryptonite
Solo iCRPGers may want to give this kind of mechanic a try as well.